Castor Oil Ethoxylates By Gujarat Chemicals

POLYETHOXYLATED CASTOR OIL
The standard Gujchem series of Polyethoxylated castor oil is GUJCHEM CO.Empirical Formula
Polyoxyethylene castor oil derivatives are complex mixtures of various hydrophobic and hydrophilic components.
In
GUJCHEM-CO 35 castor oil the hydrophobic constituents comprise about
83% of the total mixture, the main component being glycerol
polyethylene glycol ricinoleate. Other hydrophobic constituents include
fatty acid esters of polyethylene glycol along with some unchagned
castor oil. The hydrophilic part (17%) consists of polyethylene glycols
and glycerol ethoxylates.
In
GUJCHEM-CO-40, approximately 75% of the componenets of the mixture are
hydrophobic. These comprise mainly fatty acid esters of glycerol
polyethylene glycol and fatty acid esters of polyethylene glycol. The
hydrophilic portion consists of polyethylene glycols and glycerol
ethoxylates.


GUJCHEM
APPEARANCE AT 30 c
HYDROXYL VALUE
IODINE VALUE
HLB
SOLID CONTENT MIN.%
WATER CONTENT MAX.%


CO-2.5
Pale yellow viscous liquid
1475
48-58
2.14
99.5
0.2


CO-5.0
Pale yellow viscous liquid
1335
43-53
3.87
99.5
0.2


CO-10
Pale yellow viscous liquid
1115
35-45
6.49
99.5
0.2


CO-20
Pale yellow viscous liquid
855
25-35
9.8
99.5
0.2


CO-30
Pale yellow viscous liquid
685
19-29
11.8
99.5
0.2


CO-35
Pale yellow viscous liquid
605
17-27
12.54
99.5
0.2


CO-40
Pale yellow viscous liquid
565
15-25
13.15
99.5
0.2


CO-50
Pale yellow to waxy solid
555
10-20
14.83
99.5
0.2


CO-60
Pale yellow to waxy solid
415
10-15
15.0
99.5
0.2


CO-80
Pale yellow to waxy solid
335
8-12
16.0
99.5
0.2


CO-100
Pale yellow to waxy solid
285
7-11
16.7
99.5
0.2


CO-200
Pale yellow to waxy solid
155
7-11
18.2
99.5
0.2


HCO-20
yellow liquid
70-90
60-70
10.90
99.5
0.2


HCO-40
Waxy Liquid
60-80
50-60
14.10
99.5
0.2


HCO-60
Waxy Liquid
50-70
40-50
15.65
99.5
0.2


STABILITY AND STORAGE CONDITIONS :
GUJCHEM-CO-35
forms stable solutions in many organic solvents such as chloroform,
ethanol and propan-2-ol; it also forms clear, stable, aqueous
solutions.GUJCHEM-CO-35 is miscible with other polyoxyethylene castor
oil derivatives and on heating with fatty acids, fatty alcohols and
some animal and vegetable oils. Solutions of GUJCHEM-CO-40 in aquenous
alcohols are also stable.
On
heating an aqueous solution the solubility of GUJCHEM-CO-35 is reduced
and the solution becomes turbid. Aqueous solutions of polyoxyl castor
oil heated for prolonged periods may separate into solid and liquid
phases on cooling. However, the product can be restored to its original
form by homogenization.
Aqueous
solutions of GUJCHEM-CO-35 are stable in the presence of low
concentrations of electrolytes such as acids or salts, with the
exception of mercuric chloride.
Aqueous
solutions of GUJCHEM-CO-35 can be sterilized by autoclaving for 20
minutes at 121 oC. In this process a product may acquire a deeper color
although this has no significance for product stability. Aqueous
solutions of polyoxyl castor oil can similarly be sterilized by
autoclaving at 121 oC, but this may cause a slight decrease in the pH
value.
Polyoxyethylene
castor oil derivatives should be stored in a well-filled, airtight
container, protected from light, in a cool, dry, place.
SAFETY :
Polyoxyethylene castor oil derivatives are used in a variety of oral, topical and parenteral pharmaceutical formulations.
Acute
and chronic toxicity tests in animals have shown polyoxyethylene castor
oil derivatives to be essentially nontoxic and nonirritant materials.
However, several serious anaphylactic reactions have been observed in
humans and animals following parenteral, and more rarely, oral
administration of formulations containing polyoxyethylene castor oil
derivatives.
HANDLING PRECAUTIONS :
Observe
normal precautions appropriate to the circumstances and quantity of
material handled. Eye protection and gloves are recommended.
Applications in Pharmaceutical Formulation or Technology
Polyoxyethylene
castor oil derivatives are nonionic surfactants used in oral, topical
and parenteral pharmaceutical formulations. They are also used in
cosmetics animal feeds and Textile.
GUJCHEM-CO-35
is mainly used as an emulsifing and solubilizing agent, and is
particularly suitable for the production of aqueous liquid preparations
containing volatile oils, fat-soluble vitamins and other hydrophobic
substances.
GUJCHEM-CO-35
has also been used as a solvent in proprietary injections of diazepam,
propanidid and alfaxalone with alfadolone acetate. GUJCHEM-CO-35 is
also used in the production of glycerin suppositories.
In
veterinary practice, GUJCHEM-CO-35 can be used to emulsify cod liver
oil, and oils and fats incorporated into animal feeding stuffs.
In
cosmetics, GUJCHEM-CO-35 is mainly used as a solubilizing agent for
perfume bases and volatile oils in vehicles containing 30-50% v/v
alcohol (ethanol or propan-2-ol). In hand lotions it can be used to
replace castor oil.
GUJCHEM-CO-40
may be used in preference to GUJCHEM-CO-35 in oral formulations since
it is almost tasteless. In aqueous alcoholic or completely aqueous
solutions, GUJCHEM-CO-40 can be used to solubilize vitamins, essential
oils and certain drugs. Other materials which can be solubilized are;
alfadolone; alfaxalone; hexacholrophane; hexetidine; methotrimeprazine;
miconazole; propanidid; and thiopentone.
In
aerosol vehicles which include water, the addition of GUJCHEM-CO-40
improves the solubility of the propellant in the aqueous phase. This
enhancement applies both to dichlorodifluoromethane and to
propane/butane mixtures.
Foam
formation in aqueous ethanol solutions containing GUJCHEM-CO-40 can be
suppressed by the addition of small amounts of polypropylene glycol
2000.
GUJCHEM-CO-40 is also used as an emulsifier of fatty acids and alcohols.
FUNCTIONAL CATEGORY :
Emulsifier,
Co-emulsifier, Dispersant, Solubilizer, Lubricant, Antistant, Emclient
Wetting agent, Scouring agent, Deformer, Softner, Lubricant, Visco sity
control Agent, Dying Assistant Dye Carrier, Levelling agent,
Stabilizer, Penetrant.

Note: Above
Gujchem Range are the running products. We can produce higher moles
on customer specific demand and specifications can be altered as per
customer requirement.