Pantoprazole By Global Pharma

 PantoprazolePantoprazole is a proton pump inhibitor. It is a prodrug. After
administration it diffuses in to the parietal cell of the stomach and
accumulates in the secretory canaliculi. In the acidic medium
pantoprazole is converted to sulfenamide. This sulfenamide covalently
interacts with sulfhydryl (sh) group in the proton pump (h+ k+atpase)
and inhibits the exchange of extracellular k+ for intracellular h+ ion.
Pantoprazole irreversibly inhibits proton pumps activity and decreases
gastric acid secretion. Pantoprazole is more acid stable and its
activity is lowered in higher ph. It is the only proton pump inhibitor
which is available as parenteral form.