Penicillin Potassium For Injection Veterinary Raw Materials

About Penicillin Potassium For Injection

Composition
Each vial contains penicillin sodium 1.6 MIU/4.0 MIU

Characters

This product is white or almost white sterile powder.

Indication

Mainly used for Gram-positive bacteria infection, also used for actinomycetes and leptospirosis and other infections.


Superiority
Penicillin Potassium for Injection

[Main ingredient] penicillin potassium

[Characters] This product is white crystalline powder.

[Pharmacological effects]

Pharmacodynamics Penicillin is a bactericidal antibiotic, antibacterial activity is strong, its antibacterial mechanism is mainly to inhibit bacterial cell wall mucins synthesis. Sensitive bacteria in the growth stage are highly fragmented and the cell wall is in the stage of biosynthesis. Under the action of penicillin, the synthesis of the sticky peptide can not form the cell wall, and under the action of osmotic pressure, the cell membrane ruptures and dies. Non-growth and reproduction of bacteria, this time without the need for cell wall synthesis, penicillin can not afford bactericidal effect, should not penicillin such a breeding season bactericidea and inhibit bacterial growth and reproduction of a fast bacteriostatic agenta (such as fluorobenzene Nico, tetracyclines, erythromycin, etc.). The latter makes the bacteria in a state of growth inhibition, resulting in penicillin can not play a role.

Penicillin is a narrow-spectrum antibiotic, mainly to a variety of Gram-positive bacteria and a few Gram-negative bacteria. The main sensitive bacteria Staphylococcus aureus, Streptococcus, Erysipelomyces, Corynebacterium, Clostridium tetani, actinomycetes, Bacillus anthracis, spirochetes and so on. Mycobacterium, mycoplasma, chlamydia, rickettsia, nocardia, fungi and viruses are not sensitive.

Pharmacokinetics Penicillin potassium absorption rapidly after intramuscular injection, 15 to 30 minutes to reach peak plasma concentration, intramuscular injection of plasma concentration remained 0.5I g / ml for more than 6 to 7 hours. Penicillin can be widely distributed throughout the body tissues and can enter the fetal circulation, with higher concentrations of kidney, liver, lung, muscle, small intestine and spleen; lower levels of bone, saliva and milk. Difficult to enter the cerebrospinal fluid, its concentration in normal cerebrospinal fluid plasma concentration of only 1% to 3%, when the concentration of CSF in inflammation up to 5% to 30% of plasma concentration. The concentration of penicillin in milk can be 5% to 20% of the plasma concentration. Intramuscular injection of penicillin, the first few hours can be a lot of absorption, but the milk can maintain the antibacterial concentration to a considerable length of time. It has been reported that 100 000 units of penicillin aqueous solution are infused into the milk chamber, which retains 4.26 units / ml to 24 hours in the milk.

Penicillin a small part of the liver metabolism, most of the prototype excretion. In normal circumstances, 50% to 75% of renal excretion, of which 90% through the renal tubular secretion, due to the rapid discharge, so eliminate the body faster. Penicillin plasma protein binding rate of about 50%. Short half-life, small differences between species, all livestock half-life of 0.5 to 1.2 hours. Apparent distribution volume is also small, usually 0.2 ~ 0.3L / kg, higher plasma concentrations, tissue concentrations lower.