Pyronem

PyronemIndications Pneumonia, including community Acquired Pneumonia and Nosocomial PneumoniaGynaecological infections such as Endometritis and PIDComplicated Intra-Abdominal infectionsComplicated urinary tract infectionsAcute bacterial meningitisSepticaemiaAdvantagesUseful as Presumptive Therapy prior to the identification of causative organisms because of its broad spectrum of bactericidal activityExcellent CNS and Gastro-interstinal tolerability in Pediatric and Adult patientsMore effective than Ceftazidime (56% vs 40%) or Piperacillin-Tazobactam in Febrile Neutropenia (64% vs 50%)100% cure rates in Sepsis and 87.5% in Nosocomial PneumoniaNo adjustments required for patients with Hepatic impairmentAs safe as Cephalosporins with respect to incidence of seizuresMost active agent in Indian setting for ESBlsVery low incidence of Seizures (0.07%)Low incidence of adverse effect Dosage & Administration Adult Dose Paediatric Dose Pneumonia: 500mg/1g IV every 8 hrs 3 months-12 yrs UTI: 500mg/IV every 8 hrs 10-40 mg/kg Peritonitis: Ig IV every 8 hrs IV every 8 hrs Neutropenia: 1g IV every 8hrs Septicaemia: 1g IV every 8 hrs Meningitis: 2g IV every 8 hrs