Human Vkorc1 And Cyp2c9 Gene Polymorphism Detection Kit Grade: Premium

Our company is widely praised in exporting, manufacturing and supplying a huge spectrum of Human VKORC1 and CYP2C9 Gene Polymorphism Detection Kit in Wuhan, Hubei, China. Warfarin (Coumadin) is the most widely prescribed oral anticoagulant drug for the prevention and treatment of thrombotic disorders in North America1. Warfarin is a potent inhibitor of VKORC1 (vitamin K epoxide reductase complex, subunit 1), which is required for converting to Vitamin K to its reduced form (VitKH2). Anticoagulation occurs when Warfarin inhibits VKOR, decreasing the amount of VitKH2 available to activate vitamin K-dependent coagulation factors II, VII, IX, and X.
While Warfarin is a well-accepted therapy for many conditions, it has some serious side effects including excessive bleeding that can be life-threatening. Because of genetic variations, different people may response to Warfarin differently and thus be under dosed or overdosed. Patients with a variation, -1639G>A, in the promoter region of VKORC1 gene are more sensitive to Warfarin and need lower doses than those without the variation. The CYP2C9 gene encodes one of the main enzymes involved in metabolizing warfarin into inactive hydroxylated metabolites. Several CYP2C9 alleles such as CYP2C9*2 and CYP2C9*3 are associated with reduced enzyme activity to convert Warfarin into inactive form. Patients carrying at least one copy of such a variant allele will need a lower daily Warfarin dose than those having normal CYP2C9 activity.