Ketoprofen Micro Pellets

We are considered as a reputed firm, we are engaged in manufacturing, supplying and exporting a wide range of Ketoprofen Micro Pellets in Mumbai, Maharashtra, India. An emulsion-congealing technique was used to prepare prolonged release lipid micropellets containing ketoprofen. The lipid matrix consisted of cottonseed oil/beeswax mixture and was emulsified at 70A C into 0.1 N HCI containing Tween 60 and gelatin. The studied formulation factors were the amounts of drug, Tween 60 and gelatin, in addition to the matrix composition and rate of cooling. The optimization protocol required preliminary formulation studies (11 batches) to help choose suitable levels for formulation factors, and a central composite design (17 batches) to correlate simultaneously some of these factors to measured variables, e.g., drug entrapment, particle size and dissolution parameters. The adopted optimization strategy led to formulation of micropellets of about 1.5 mm in diameter and 25% w/w drug loading with prolonged release characteristics. The study design offers adequate prediction of micropellet characteristics and provides a basis for development of other micropellet systems.