Recombinant Igg Production
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We are a recognized service provider in converting small gene-engineered scFv or Fab human/mouse antibodies derived from phage display antibody librar...View Product Details
Product Overview
Key Features
We are a recognized service provider in converting small gene-engineered scFv or Fab human/mouse antibodies derived from phage display antibody library screening or mouse/rat hybridoma cell lines into full-size recombinant human or mouse IgGs with Fc fragments of various functions, e.g. ADCC, or non-ADCC. Creative Biolabs have established a solid platform for industrial scale production of recombinant IgG in mammalian cells.
Of note, to mimic the behavior of a recombinant human IgG antibody [targeting a human protein] in humans the best, specificity-matching recombinant mouse IgG antibodies derived from phage display mouse scFv/Fab libraries [targeting the mouse protein] are frequently produced and used in animal models.
We use a modified FRT/Flp-In recombinase system to produce human IgG in CHO cells for stable expression of humanized/recombinant human IgG. The same approach is used in stable expression of recombinant mouse IgG. We have pre-selected CHO cell lines that contain a single stably integrated FRT site at a transcriptionally active genomic locus and we have proven that they can produce high level expressers of recombinant human IgGs [targeting various antigens]. Unfortunately, even starting from these pre-selected cell lines, significant amount of time and effort are required to create a stable cell line that can express recombinant human [mouse] IgG at a cost-effective level, e.g. 800mg/L.
Of note, to mimic the behavior of a recombinant human IgG antibody [targeting a human protein] in humans the best, specificity-matching recombinant mouse IgG antibodies derived from phage display mouse scFv/Fab libraries [targeting the mouse protein] are frequently produced and used in animal models.
We use a modified FRT/Flp-In recombinase system to produce human IgG in CHO cells for stable expression of humanized/recombinant human IgG. The same approach is used in stable expression of recombinant mouse IgG. We have pre-selected CHO cell lines that contain a single stably integrated FRT site at a transcriptionally active genomic locus and we have proven that they can produce high level expressers of recombinant human IgGs [targeting various antigens]. Unfortunately, even starting from these pre-selected cell lines, significant amount of time and effort are required to create a stable cell line that can express recombinant human [mouse] IgG at a cost-effective level, e.g. 800mg/L.
Company Details
Creative Biolabs, Established in 2004 at New York in New York, is a leading service provider of Others in United States. Creative Biolabs is one of Trade India's verified and trusted names for listed services. With extensive experience in the field of Others, Creative Biolabs has made a reputed name for itself in the market with satisfactory Anti-Hapten Antibody Production, Antibody Affinity Maturation, Antibody And Protein Purification Service, etc.
Focusing on a customer-centric approach, Creative Biolabs has a pan-India presence and caters to a huge consumer base throughout the country. Get Others from Creative Biolabs at Trade India quality-assured services.
Focusing on a customer-centric approach, Creative Biolabs has a pan-India presence and caters to a huge consumer base throughout the country. Get Others from Creative Biolabs at Trade India quality-assured services.
Business Type
Manufacturer, Service Provider, Supplier
Employee Count
1
Establishment
2004
Working Days
Monday To Sunday
Seller Details
C
Creative Biolabs
Name
Mr. Bella Smith
Address
SUITE 203, 17 Ramsey Road, Shirley, New York, New York, 11967, United States
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