Tizanidine Ip/bp/usp/ep Application: Medicine

Niksan Pharmaceutical and the Niksan group companies are the worlda s top most leading pharmaceutical companies in the exporting, supplying and manufacturing Tizanidine API and also the finished pharmaceutical products of Tizanidine like Tizanidine tablets and Tizanidine formulations. Niksan Pharmaceuticala s Tizanidine product is appreciated widely by our group companies and by the customers all around the world.

Niksan Pharmaceutical provides API and finished formulations of Tizanidine in all over Indian states like Andhra Pradesh, Telangana, Punjab, Maharashtra, West Bengal, Karnataka, Kerala, Madhya Pradesh, Pondicherry, Dadra and Nagar Haveli, , Orissa, Punjab, Rajasthan, Sikkim, Tamil Nadu, Goa, Gujarat, Jammu and Kashmir and other more Indian states.

Niksan Pharmaceutical is also large exporters of the API and finished pharmaceutical products of Tizanidine in many countries for years. The countries where we exporting are Puerto Rico, United States, Nepal, Pakistan, Nigeria, Bangladesh, Saudi Arabia, UAE, Ireland, Philippines, Iran, Canada, Indonesia, Finland, Thailand, Egypt, Vietnam, UK, Taiwan, Netherlands, Poland, Australia, Mexico, Germany, France etc.

Tizanidine used in treatment of spinal code injury or multiple sclerosis.
Tizanidine is a class of drug called skeletal muscle relaxants. Tizanidine works by slowing action in the brain and nervous system.

SYNONYMS: Tizanidin, Tizanidina, Tizanidine, Tizanidinum

IUPAC NAME: 5-chloro-N-(4, 5-dihydro-1H-imidazol-2-yl)-2, 1, 3-benzothiadiazol-4-amine

CAS NO: 51322-75-9

FORMULA: C9H8ClN5S

MOLECULAR MASS: 253.71 g/mol

STORAGE OF TIZANIDINE: Store at room temperature (15-30 degree C). Keep away from children and pets. Keep away from moisture and direct light. Do not freeze and do not store in bathroom or any humidly place.

APPLICATIONS OF TIZANIDINE: Tizanidine is used to control muscle spasms. This drug also used for treatment of multiple sclerosis, spinal cord injury, or muscle spasticity. Mainly used in treatment of brain or spinal cord injuries

HOW TO USE: Tizanidine is taken by mouth. In one day, you can take Tizanidine medicine up to 3 times. Take Tizanidine with or without food, but take it the same way each time for better result.

HOW TIZANIDINE WORKS: Tizanidine act as a muscle relaxant by blocking the nerve impulse.

CONTRAINDICATIONS OF TIZANIDINE: Do not take Tizanidine if you have Hepatic disease and Psychosis. Kindly avoid Tizanidine if you have any Hypotension and renal failure. Do not share your medication with other person. Take your doctora s recommendation if any adverse reactions appear while taking the treatment of Tizanidine.

PHARMACOKINETICS OFTIZANIDINE: Absorption is approximately 40% when you take Tizanidine by oral administration. Tizanidine half-life is about 150 minutes. Approximately 95% of an administered dose is metabolized. Tizanidine has peak plasma concentrations occurring 1 hour after dosing. The major excretory route of Tizanidine is being via the kidneys.

SIDE EFFECTS OF TIZANIDINE: The most common side effect of Tizanidine is dizziness, drowsiness, weakness, nervousness, hallucinations and depression. Other side effects like vomiting, dry mouth, constipation, diarrhea, stomach pain, heartburn, increased muscle spasms are also seen in patients. The very serious side effects to this medicine are rare. But if you notice any kind of allergy like rash or itching, get medical help from your doctor.

PRECAUTIONS: Before using this medicine tell your doctor about your medical history especially if you are an allergic to Tizanidine. Tizanidine may make you dizzy and drowsy so kindly avoid taking alcohol during the dose of this medicine and avoid driving. Tizanidine contain inactive ingredient which can cause some allergic problem and other problems. Discuss with your doctor before breast-feeding. Because it is unknown if drug passes into breast. During the pregnancy kindly avoid Tizanidine or consult with your doctor.

CDSCO APPROVAL: Tizanidine hcl tablets are approved by CDSCO in India in 22.12.1993
Mefenamic acid + Tizanidine tablets are approved by CDSCO in India in 12.07.2002
Aceclofenac 100mg + Tizanidine 2mg film coated tablets are approved by CDSCO in India in 23.02.2009

FORMULATION AVAILABLE IN MARKET:
Tizanidine 2 MG tablets
Tizanidine 4 MG tablets
Ibuprofen 400 MG+Tizanidine 2 MG tablets
Nimesulide 100 MG+Tizanidine 2 MG tablets
Diclofenac 50 MG+Serratiopeptidase 10 MG+Tizanidine 2 MG tablets
Nimesulide 200 MG+Tizanidine 2 MG tablets
Diclofenac 50 MG+Paracetamol 325 MG+Tizanidine 2 MG tablets
Diclofenac 50 MG+Nimesulide 100 MG+Tizanidine 2 MG tablets
Mefenamic Acid 500 MG+Tizanidine 2 MG tablet
Tizanidine HCl tablets
Mefenamic acid + Tizanidine tablets
Aceclofenac 100mg + Tizanidine 2mg film coated tablets

Note: Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk.

REFERENCES:

www.webmd.com
https://pubchem.ncbi.nlm.nih.gov
https://go.drugbank.com
https://cdscoonline.gov.in
https://www.wikipedia.org/
https://www.drugs.com
https://www.zaubacorp.com
https://www.practo.com/consult