Hcg Injection By Sanzyme (P) Ltd.

COMPOSITION: 
Each ampoule contains lyophilized preparation of Human Chorionic Gonadotropin I.P.
1000, 2000, 5000 & 10000 I.U.


INDICATIONS:
In
Females: To induce ovulation, Primary/ Secondary Amenorrhora, Habitual/
Recurrent abortions, To maitain luteal function.
In Males: Oligospermia, Asthenosperimia,
Hypogonadotropoc Hypogonadism, Cryptorchidism
ACTIONS:
The action of PUBERGEN
(hCG) is virtually identical to that of pituitary LH, although hCG appears
to have a small degree of FSH activity as well.
IN FEMALE INFERTILITY:


hCG maintains the corpus luteum to produce progesterone Acts on corpus luteum to maintain luteal functionInduces ovulation Maintain luteal functions Helps in conception

IN MALE INFERTILITY:

Stimulates the interstitial cells (Leydig cells) of the testes to
produce androgens Helps release of ICSH (Interstitial Cell Stimulating Hormone) Helps in spermatogenesis Induces testicular descent Helps in Hypogonadotrophic Hypogonadism


DOSAGE:

Females: To
induce ovulation : 5000-10000 I.U. one injection on 12th day of menstural
cycle, or when the graafian follicle attains a size >18mm.
Habitual / Recurrent
Abortions : Once pregnancy is confirmed, inject 5000 I.U. of PUBERGEN
per day on three alternate days. From the 9th day of the first injection,
2000 I.U. twice a week, till the 14th week of pregnancy.
Males:
5000 I.U. twice weekly, for 12 weeks & may have to be continued even
upto to 1 year to improve semen quality.  
CONTRAINDICATIONS:
 
Precocious puberty, prostatic
carcinoma, or other androgen dependent neoplasia, prior allergic reaction
to chorionic gonadotrophin.

PRECAUTIONS:
 
hCG should be used by
Physicians familiar with infertility problems. The principle reactions
during the use are : Ovarian hyperstimulation syndrome, Ovarian enlargement,
multiple births.
Induction of Androgen
secretion by chorionic gonadotrophin may induce precocious puberty in
patient with Cryptorchidism.
ADVERSE REACTIONS:



Headache, irritability,
edema, restlessness, depression, tiredness, precocious puberty, gynaecomastia
& pain at the site of injection.
STORAGE:



To
be stored under refrigeration between 80C to 200C. Do not freeze.
PRESENTATION:

PUBERGEN 1000 I.U. :
Box containing 1 ampoule of hCG & 1 ampoule solvent.
PUBERGEN 2000 I.U. : Box containing 1 ampoule of hCG & 1 ampoule
solvent.
PUBERGEN 5000 I.U. : Box containing 1 ampoule of hCG & 1 ampoule
solvent.
PUBERGEN 10000 I.U. : Box containing 1 ampoule of hCG & 1 ampoule
solvent.
(Sterile Sodium Chloride
Injection I.P. 0.9%w/v)
FOR INTRA MUSCULAR
USE ONLY.